Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.
Identifieur interne : 000463 ( Main/Exploration ); précédent : 000462; suivant : 000464Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.
Auteurs : RBID : pubmed:24167080English descriptors
- KwdEn :
- Animals, Antigens, Neoplasm (genetics), Antigens, Neoplasm (metabolism), Biological Markers (metabolism), Endpoint Determination, Idiopathic Pulmonary Fibrosis (metabolism), Idiopathic Pulmonary Fibrosis (pathology), Idiopathic Pulmonary Fibrosis (radiography), Idiopathic Pulmonary Fibrosis (radionuclide imaging), Indium Radioisotopes (diagnostic use), Integrins (genetics), Integrins (metabolism), Lung (metabolism), Lung (pathology), Lung (radiography), Lung (radionuclide imaging), Male, Mice, Mice, Inbred C57BL, Multimodal Imaging, Peptides (diagnostic use), Prognosis, RNA, Messenger (genetics), RNA, Messenger (metabolism), Signal Transduction, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
- MESH :
- chemical , diagnostic use : Indium Radioisotopes, Peptides.
- chemical , genetics : Antigens, Neoplasm, Integrins, RNA, Messenger.
- chemical , metabolism : Antigens, Neoplasm, Biological Markers, Integrins, RNA, Messenger.
- metabolism : Idiopathic Pulmonary Fibrosis, Lung.
- pathology : Idiopathic Pulmonary Fibrosis, Lung.
- radiography : Idiopathic Pulmonary Fibrosis, Lung.
- radionuclide imaging : Idiopathic Pulmonary Fibrosis, Lung.
- Animals, Endpoint Determination, Male, Mice, Mice, Inbred C57BL, Multimodal Imaging, Prognosis, Signal Transduction, Tomography, Emission-Computed, Single-Photon, Tomography, X-Ray Computed.
Abstract
Transforming growth factor β activation by the αvβ6 integrin is central to the pathogenesis of idiopathic pulmonary fibrosis. Expression of the αvβ6 integrin is increased in fibrotic lung tissue and is a promising therapeutic target for treatment of the disease. Currently, measurement of αvβ6 integrin levels in the lung requires immunohistochemical analysis of biopsy samples. This procedure is clinically impractical for many patients with pulmonary fibrosis, and a noninvasive strategy for measuring αvβ6 integrin levels in the lungs is urgently required to facilitate monitoring of disease progression and therapeutic responses.
DOI: 10.2967/jnumed.113.120592
PubMed: 24167080
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.</title><author><name sortKey="John, Alison E" uniqKey="John A">Alison E John</name><affiliation wicri:level="1"><nlm:affiliation>Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nottingham Respiratory Research Unit, University of Nottingham, Nottingham</wicri:regionArea></affiliation></author><author><name sortKey="Luckett, Jeni C" uniqKey="Luckett J">Jeni C Luckett</name></author><author><name sortKey="Tatler, Amanda L" uniqKey="Tatler A">Amanda L Tatler</name></author><author><name sortKey="Awais, Ramla O" uniqKey="Awais R">Ramla O Awais</name></author><author><name sortKey="Desai, Ami" uniqKey="Desai A">Ami Desai</name></author><author><name sortKey="Habgood, Anthony" uniqKey="Habgood A">Anthony Habgood</name></author><author><name sortKey="Ludbrook, Steve" uniqKey="Ludbrook S">Steve Ludbrook</name></author><author><name sortKey="Blanchard, Andy D" uniqKey="Blanchard A">Andy D Blanchard</name></author><author><name sortKey="Perkins, Alan C" uniqKey="Perkins A">Alan C Perkins</name></author><author><name sortKey="Jenkins, R Gisli" uniqKey="Jenkins R">R Gisli Jenkins</name></author><author><name sortKey="Marshall, John F" uniqKey="Marshall J">John F Marshall</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="RBID">pubmed:24167080</idno><idno type="pmid">24167080</idno><idno type="doi">10.2967/jnumed.113.120592</idno><idno type="wicri:Area/Main/Corpus">000341</idno><idno type="wicri:Area/Main/Curation">000341</idno><idno type="wicri:Area/Main/Exploration">000463</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Neoplasm (genetics)</term><term>Antigens, Neoplasm (metabolism)</term><term>Biological Markers (metabolism)</term><term>Endpoint Determination</term><term>Idiopathic Pulmonary Fibrosis (metabolism)</term><term>Idiopathic Pulmonary Fibrosis (pathology)</term><term>Idiopathic Pulmonary Fibrosis (radiography)</term><term>Idiopathic Pulmonary Fibrosis (radionuclide imaging)</term><term>Indium Radioisotopes (diagnostic use)</term><term>Integrins (genetics)</term><term>Integrins (metabolism)</term><term>Lung (metabolism)</term><term>Lung (pathology)</term><term>Lung (radiography)</term><term>Lung (radionuclide imaging)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Multimodal Imaging</term><term>Peptides (diagnostic use)</term><term>Prognosis</term><term>RNA, Messenger (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Signal Transduction</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Peptides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Neoplasm</term><term>Integrins</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Neoplasm</term><term>Biological Markers</term><term>Integrins</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Idiopathic Pulmonary Fibrosis</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Idiopathic Pulmonary Fibrosis</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Idiopathic Pulmonary Fibrosis</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Idiopathic Pulmonary Fibrosis</term><term>Lung</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Endpoint Determination</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Multimodal Imaging</term><term>Prognosis</term><term>Signal Transduction</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tomography, X-Ray Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Transforming growth factor β activation by the αvβ6 integrin is central to the pathogenesis of idiopathic pulmonary fibrosis. Expression of the αvβ6 integrin is increased in fibrotic lung tissue and is a promising therapeutic target for treatment of the disease. Currently, measurement of αvβ6 integrin levels in the lung requires immunohistochemical analysis of biopsy samples. This procedure is clinically impractical for many patients with pulmonary fibrosis, and a noninvasive strategy for measuring αvβ6 integrin levels in the lungs is urgently required to facilitate monitoring of disease progression and therapeutic responses.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24167080</PMID><DateCreated><Year>2013</Year><Month>12</Month><Day>03</Day></DateCreated><DateCompleted><Year>2014</Year><Month>02</Month><Day>04</Day></DateCompleted><DateRevised><Year>2014</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1535-5667</ISSN><JournalIssue CitedMedium="Internet"><Volume>54</Volume><Issue>12</Issue><PubDate><Year>2013</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of nuclear medicine : official publication, Society of Nuclear Medicine</Title><ISOAbbreviation>J. Nucl. Med.</ISOAbbreviation></Journal><ArticleTitle>Preclinical SPECT/CT imaging of αvβ6 integrins for molecular stratification of idiopathic pulmonary fibrosis.</ArticleTitle><Pagination><MedlinePgn>2146-52</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2967/jnumed.113.120592</ELocationID><Abstract><AbstractText Label="UNLABELLED">Transforming growth factor β activation by the αvβ6 integrin is central to the pathogenesis of idiopathic pulmonary fibrosis. Expression of the αvβ6 integrin is increased in fibrotic lung tissue and is a promising therapeutic target for treatment of the disease. Currently, measurement of αvβ6 integrin levels in the lung requires immunohistochemical analysis of biopsy samples. This procedure is clinically impractical for many patients with pulmonary fibrosis, and a noninvasive strategy for measuring αvβ6 integrin levels in the lungs is urgently required to facilitate monitoring of disease progression and therapeutic responses.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Using a murine model of bleomycin-induced lung injury, we assessed the binding of intravenously administered (111)In-labeled αvβ6-specific (diethylenetriamine pentaacetate-tetra [DTPA]-A20FMDV2) or control (DTPA-A20FMDVran) peptide by nanoSPECT/CT imaging. Development of fibrosis was assessed by lung hydroxyproline content, and αvβ6 protein and itgb6 messenger RNA were measured in the lungs.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Maximal binding of (111)In-labeled A20FMDV2 peptide to αvβ6 integrins was detected in the lungs 1 h after intravenous administration. No significant binding was detected in mice injected with control peptide. Integrin binding was increased in the lungs of bleomycin-, compared with saline-, exposed mice and was attenuated by pretreatment with αvβ6-blocking antibodies. Levels of (111)In-labeled A20FMDV2 peptide correlated positively with hydroxyproline, αvβ6 protein, and itgb6 messenger RNA levels.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We have developed a highly sensitive, quantifiable, and noninvasive technique for measuring αvβ6 integrin levels within the lung. Measurement of αvβ6 integrins by SPECT/CT scanning has the potential for use in stratifying therapy for patients with pulmonary fibrosis.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>John</LastName><ForeName>Alison E</ForeName><Initials>AE</Initials><Affiliation>Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, United Kingdom.</Affiliation></Author><Author ValidYN="Y"><LastName>Luckett</LastName><ForeName>Jeni C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Tatler</LastName><ForeName>Amanda L</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Awais</LastName><ForeName>Ramla O</ForeName><Initials>RO</Initials></Author><Author ValidYN="Y"><LastName>Desai</LastName><ForeName>Ami</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Habgood</LastName><ForeName>Anthony</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Ludbrook</LastName><ForeName>Steve</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Blanchard</LastName><ForeName>Andy D</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Perkins</LastName><ForeName>Alan C</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Jenkins</LastName><ForeName>R Gisli</ForeName><Initials>RG</Initials></Author><Author ValidYN="Y"><LastName>Marshall</LastName><ForeName>John F</ForeName><Initials>JF</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G0901226</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_G0802525</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType>Journal Article</PublicationType><PublicationType>Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>10</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Nucl Med</MedlineTA><NlmUniqueID>0217410</NlmUniqueID><ISSNLinking>0161-5505</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Antigens, Neoplasm</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Biological Markers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Integrins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>integrin alphavbeta6</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Antigens, Neoplasm</DescriptorName><QualifierName MajorTopicYN="N">genetics</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Biological Markers</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Endpoint Determination</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Idiopathic Pulmonary Fibrosis</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="Y">radiography</QualifierName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Integrins</DescriptorName><QualifierName MajorTopicYN="N">genetics</QualifierName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lung</DescriptorName><QualifierName MajorTopicYN="N">metabolism</QualifierName><QualifierName MajorTopicYN="N">pathology</QualifierName><QualifierName MajorTopicYN="N">radiography</QualifierName><QualifierName MajorTopicYN="N">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Multimodal Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Peptides</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName MajorTopicYN="N">genetics</QualifierName><QualifierName MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Tomography, X-Ray Computed</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">SPECT/CT</Keyword><Keyword MajorTopicYN="N">fibrosis</Keyword><Keyword MajorTopicYN="N">integrin αvβ6</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>10</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24167080</ArticleId><ArticleId IdType="pii">jnumed.113.120592</ArticleId><ArticleId IdType="doi">10.2967/jnumed.113.120592</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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